Author Archives: Alex

Iso-Seq Allows Genome-Independent Transcriptome Profiling of Grape Berry Development

Posted on March 19, 2019 by Alex

March 2019 Authors: Andrea Minio, Mélanie Massonnet, Rosa Figueroa-Balderas, Amanda M. Vondras, Barbara Blanco-Ulate, and Dario Cantu Info: Researchers used PacBio’s Iso-Seq method to sequence full-length cDNA transcripts from ripening Cabernet Savignon berries resulting in 1,5000 cultivar-specific genes. The authors … more »

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Cancer stem cell–associated miRNAs serve as prognostic biomarkers in colorectal cancer

Posted on March 3, 2019 by Alex

March 2019 Authors: Shusuke Toden, Shigeyasu Kunitoshi, Jacob Cardenas, Jinghua Gu, Elizabeth Hutchins, Kendall Van Keuren-Jensen, Hiroyuki Uetake, Yuji Toiyama, and Ajay Goel Info: This study evaluates cancer stems cells (CSC) which resist chemotherapy agents and have high tumor initiation … more »

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Gestational jet lag predisposes to later-life skeletal and cardiac disease

Posted on February 3, 2019 by Alex

February 2019 Authors: Inês Chaves, Bram van der Eerden, Ruben Boers, Joachim Boers, Astrid A. Streng, Yanto Ridwan, Marijke Schreuders-Koedam, Marijn Vermeulen, Ingrid van der Pluijm, Jeroen Essers, Joost Gribnau, Irwin K. M. Reiss & Gijsbertus T. J. van der … more »

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Linked-Read Sequencing Advances Understanding of Cancers

Posted on January 28, 2019 by Alex

A new study* from the University of Connecticut Medical School, Jackson Labs, and collaborators demonstrate the utility of using emulsion based linked-read sequencing (10X Genomics) for cancer research. Published in January’s Otology & Neurotology studies patients with Neurofibromatosis Type 2 … more »

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SageELF Size Selection for PacBio Circular Consensus Sequencing

Posted on January 17, 2019 by Alex

A new preprint has landed on BioRxiv that reports on high-accuracy circular consensus sequencing (CCS) on the PacBio Sequel. The study, “Highly-accurate long-read sequencing improves variant detection and assembly of a human genome”, is authored by PacBio and an impressive … more »

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Enhanced detection of circulating tumor DNA by fragment size analysis

Posted on December 2, 2018 by Alex

November 2018 Authors: Florent Mouliere et al. Info: This study from Cancer Research UK and a large team of collaborators is a continuation of work evaluating circulating tumor DNA (ctDNA) and the significance of sub-167 base pair cell-free DNA as … more »

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Small-seq for single-cell small-RNA sequencing

Posted on October 1, 2018 by Alex

September 2018 Authors: Michael Hagemann-Jensen, Ilgar Abdullayev, Rickard Sandberg and Omid R Faridani Info: A new protocol from researchers at the Karolinska Institutet and the Ludwig Institute for Cancer Research outline a method for making small RNA sequencing libraries from … more »

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Product Update: The High Pass Plus Cassette

Posted on September 19, 2018 by Alex

The High Pass Plus™ gel cassette is the newest addition to the Pippin Family. As the name suggests, it is dedicated to our BluePippin “High-Pass” DNA size selection which has been a go-to method for increasing the read lengths for … more »

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Tracking Yellow Fever: New Study Aims To Tackle YFV Epidemics

Posted on September 12, 2018 by Alex

Last year, we posted a story about an international team of scientists who embarked on a mission with Brazilian researchers to study the dangerous mosquito-borne Chikungunya virus (“Tracking Chikungunya: New Study Traces Outbreak Path”- we were pleased to donate a … more »

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Genomic and epidemiological monitoring of yellow fever virus transmission potential

Posted on September 11, 2018 by Alex

August 2018 Authors: N.R. Faria, et al. Info: A large collaboration between international and Brazilian researchers used a suite of epidemiological, spatial, and genomic approaches to characterize Yellow Fever virus transmission in Brazil. The study potentially establishes a framework for … more »

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