Category Archives: Blog

“Range+T “ for Tight Sizing of HMW Libraries

Range+T Size Selection Note: Range + T is available for all PippinHT instruments. However, only BluePippins with serial numbers 2700 and above will run the method. Sage’s DNA size selection technology has been used to help improve PacBio sequencing, particularly … more »

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Cut the Big Stuff: >50kb High Pass DNA Size Selection on the HLS2

We have been getting quite a few inquiries of late from researchers who would like to size select DNA fragments above 50kb. This may be due in no small part to our friends at Grandomics, China, who have been citing … more »

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AGBT23 Roundup!

Well, we have another fabulous AGBT behind us that we were happy to attend.   Our take home messages? A. Spatial transcriptomics is the exciting new frontier.  B.  True human WGS  has been accomplished and is moving into population-scale work. And … more »

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HLS-CATCH and TELL-Seq: Haplotype Phasing of a 187kb HMW Gene Targets from a Trio

We here at Sage Science are excited to have joined forces with Universal Sequencing Technology to promote their TELL-Seq barcode linked-read technology.  One of the reasons for our excitement is that TELL-Seq, and the transposase-based barcoding method benefits greatly from … more »

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Unleash Your Illumina Sequencer with TELL-Seq™ Linked Reads

We’re proud to announce today that we will be selling TELL-Seq™ linked library prep kits from Universal Sequencing Technology. TELL-Seq, Transposase Enzyme Linked Long-read Sequencing, is a scalable NGS library technology with a very simple workflow that can provide you … more »

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HLS-CATCH and TELL-Seq™: a new route to Targeted Long-Fragment Linked-Read Sequencing

At the recent 2020 AGBT meeting Universal Sequencing gave a data-filled poster on their new Transposase Enzyme Linked Long-read Sequencing kit and workflow, known as TELL-Seq™. The technology features a unique combination of bead-linked and soluble transposases that can generate … more »

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SageHLS Helps Unravel the Neuropsychiatric 22q11.2 Deletion Region1q11

An international collaboration led by the Stanford labs of Alexander Urban and Hanlee Ji, used the SageHLS system to map a Mb-sized deletion in a complex region of the human genome, 22q11.2, that is associated with a variety of neurodevelopmental … more »

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SageHLS sample prep for ultra-long Nanopore Sequencing at NextOmics/GrandOmics

NextOmics/GrandOmics is the largest third-generation sequencing service company in China. The NextOmics division focuses on animal, plant and bacterial genome sequencing, while GrandOmics focuses on human genome sequencing. GrandOmics became the first certified PromethIon service provider in China in June, … more »

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AGBT 2019 Re-Cap

AGBT 2019 was a smashing success this year. Featuring a triumphant return to Marco Island FL with postcard perfect weather, the science was (as usual) top-notch. The renovated Marriott greatly upgraded its conference facilities and added an attractive new tower … more »

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Linked-Read Sequencing Advances Understanding of Cancers

A new study* from the University of Connecticut Medical School, Jackson Labs, and collaborators demonstrate the utility of using emulsion based linked-read sequencing (10X Genomics) for cancer research. Published in January’s Otology & Neurotology studies patients with Neurofibromatosis Type 2 … more »

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