Enhanced detection of circulating tumor DNA by fragment size analysis

November 2018

Florent Mouliere et al.

This study from Cancer Research UK and a large team of collaborators is a continuation of work evaluating circulating tumor DNA (ctDNA) and the significance of sub-167 base pair cell-free DNA as a marker for tumors. Samples from a cohort of 200 patients were tested and show significantly improved detection of ctDNA by size selecting DNA between 90-150 bp, and using the TAm-Seq technique to detect mutations. PippinHT was used for DNA size selection.

Science Translational Medicine
DOI: 10.1126/scitranslmed.aat4921

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