Monthly Archives: March 2017

Detecting DNA cytosine methylation using nanopore sequencing

Posted on March 25, 2017 by Alex

February 2017 Authors: Jared Simpson, Rachael Workman, PC Zuzarte, Matei David, LJ Dursi & Winston Timp Info: In this paper, scientists report developing algorithms to distinguish methylated from unmethylated DNA using the Oxford Nanopore MinION sequencer. They evaluated its performance … more »

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Evidence for concerted movement of nuclear and mitochondrial clines in a lizard hybrid zone

Posted on March 25, 2017 by Alex

February 2017 Authors: Adam D. Leaché, Jared A. Grummer, Rebecca B. Harris, and Ian K. Breckheimer Info: Scientists at the University of Washington analyzed samples collected over a 10-year period to better understand evolution of Sceloporus tristichus in a hybrid … more »

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Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution

Posted on March 25, 2017 by Alex

February 2017 Authors: Gavin G. Rutledge, Ulrike Böhme, Mandy Sanders, Adam J. Reid, et al. Info: In this paper, scientists generated a new reference genome and a manually curated draft assembly for two Plasmodium species. This effort made it possible … more »

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Subspecies delineation amid phenotypic, geographic and genetic discordance in a songbird

Posted on March 25, 2017 by Alex

February 2017 Authors: Jennifer Walsh, Irby J. Lovette, Virginia Winder, Chris S. Elphick, Brian J. Olsen, Gregory Shriver, and Adrienne I. Kovach Info: Scientists at Cornell University and other institutions analyzed sparrow populations using reduced-representation sequencing to understand the genetic … more »

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Small genomic insertions form enhancers that misregulate oncogenes

Posted on March 25, 2017 by Alex

February 2017 Authors: Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, et al. Info: In this paper, scientists report using ChIP-seq to better understand the role of non-coding somatic insertions in tumorigenesis. They identified enhancer-associated small insertions, often … more »

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Minimum sample sizes for population genomics: an empirical study from an Amazonian plant species

Posted on March 25, 2017 by Alex

February 2017 Authors: Alison G. Nazareno, Jordan B. Bemmels, Christopher W. Dick, Lúcia G. Lohmann Info: Scientists in Michigan and São Paulo, Brazil, performed ddRAD-seq on two separate populations of Amphirrhox longifolia to determine how many SNPs and organisms have … more »

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Genetic diversity of Atlantic Bluefin tuna in the Mediterranean Sea: insights from genome-wide SNPs and microsatellites

Posted on March 25, 2017 by Alex

February 2017 Authors: Aglaia Antoniou, Panagiotis Kasapidis, Georgios Kotoulas, Constantinos C. Mylonas and Antonios Magoulas Info: Scientists from the Hellenic Centre for Marine Research used ddRAD-seq to analyze genome-wide SNPs in the Atlantic Bluefin tuna, with the goal of understanding … more »

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Co-chaperone Hsp70/Hsp90 organizing protein (Hop) is Required for Transposon Silencing and piRNA Biogenesis

Posted on March 25, 2017 by Alex

February 2017 Authors: Joseph A. Karam, Rasesh Y. Parikh, Dhananjaya Nayak, David Rosenkranz and Vamsi K. Gangaraju Info: Scientists from South Carolina and Mainz, Germany, studied Hop, a co-chaperone that interacts with a piRNA in Drosophila. They found that knocking … more »

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Metagenomic survey of the taxonomic and functional microbial communities of seawater and sea ice from the Canadian Arctic

Posted on March 25, 2017 by Alex

February 2017 Authors: Etienne Yergeau, Christine Michel, Julien Tremblay, Andrea Niemi, Thomas L. King, Joanne Wyglinski, Kenneth Lee, and Charles W. Greera Info: Scientists from Canada and Australia studied how climate change may be affecting microbial communities by performing metagenomic … more »

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Two stable variants of Burkholderia pseudomallei strain MSHR5848 express broadly divergent in vitro phenotypes associated with their virulence differences

Posted on March 25, 2017 by Alex

February 2017 Authors: A. A. Shea, R. C. Bernhards, C. K. Cote, C. J. Chase, et al. Info: Scientists from the United States Army Medical Research Institute of Infectious Diseases compared two strains of Burkholderia pseudomallei to find variants that … more »

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