Two stable variants of Burkholderia pseudomallei strain MSHR5848 express broadly divergent in vitro phenotypes associated with their virulence differences

February 2017

A. A. Shea, R. C. Bernhards, C. K. Cote, C. J. Chase, et al.

Scientists from the United States Army Medical Research Institute of Infectious Diseases compared two strains of Burkholderia pseudomallei to find variants that might explain why one version was significantly more lethal than the other. They hope this work could lead to biomarkers in cases of infection. For genome analysis, they used BluePippin to size-select libraries for PacBio sequencing.

PLoS One

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