Co-chaperone Hsp70/Hsp90 organizing protein (Hop) is Required for Transposon Silencing and piRNA Biogenesis

February 2017

Joseph A. Karam, Rasesh Y. Parikh, Dhananjaya Nayak, David Rosenkranz and Vamsi K. Gangaraju

Scientists from South Carolina and Mainz, Germany, studied Hop, a co-chaperone that interacts with a piRNA in Drosophila. They found that knocking down Hop activates transposons and that it has an important role in maintaining genome integrity. RNA-seq was performed on an Illumina HiSeq 2500 after Pippin Prep was used for size selection.

Journal of Biological Chemistry
doi: 10.1074/jbc.C117.777730

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