Small genomic insertions form enhancers that misregulate oncogenes

February 2017

Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, et al.

In this paper, scientists report using ChIP-seq to better understand the role of non-coding somatic insertions in tumorigenesis. They identified enhancer-associated small insertions, often near oncogenes. Pippin Prep was used in the ChIP-seq protocol to capture 200 bp – 400 bp fragments ahead of sequencing on an Illumina HiSeq 2500.

Nature Communications

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