Author Archives: Alex

Defining an olfactory receptor function in airway smooth muscle cells

Posted on January 6, 2017 by Alex

December 2016 Authors: William H. Aisenberg, Jessie Huang, Wanqu Zhu, Premraj Rajkumar, et al. Info: Scientists at Johns Hopkins University, Rutgers, and other institutions teamed up to study receptors in airway smooth muscle cells that appear to play a role … more »

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The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity

Posted on January 6, 2017 by Alex

December 2016 Authors: Samer G. Alam, Qiao Zhang, Nripesh Prasad, Yuan Li, Srikar Chamala, et al. Info: Researchers from the HudsonAlpha Institute, the University of Florida, and other institutions studied the role of rigidity in the extracellular matrix, finding that … more »

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Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

Posted on January 6, 2017 by Alex

December 2016 Authors: Peter Ly, Levi S. Teitz, Dong H. Kim, Ofer Shoshani, Helen Skaletsky, Daniele Fachinetti, David C. Page, and Don W. Cleveland Info: Scientists report developing a strategy to examine what happens when chromosomes do not segregate properly. … more »

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Susceptibility to Aminoglycosides and Distribution of aph and aac(3)-XI Genes among Corynebacterium striatum Clinical Isolates

Posted on January 6, 2017 by Alex

December 2016 Authors: Jesús Navas, Marta Fernández-Martínez, Carlos Salas, María Eliecer Cano, Luis Martínez-Martínez Info: Scientists in Spain analyzed several strains of the pathogen Corynebacterium striatum and found that many were resistant to drugs most commonly used to treat these … more »

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Single-Molecule Sequencing (PacBio) of the Staphylococcuscapitis NRCS-A Clone Reveals the Basis of Multidrug Resistance and Adaptation to the Neonatal Intensive Care Unit Environment

Posted on January 6, 2017 by Alex

December 2016 Authors: Patrícia MartinsSimões, HajarLemriss, YannDumont, SanâaLemriss, et al. Info: Scientists in France and Morocco fully sequenced the genome and accessory genome of a Staphylococcus capitis clone that has proven resistant to many drugs and is particularly detrimental to … more »

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Farewell to 2016

Posted on December 20, 2016 by Alex

As 2016 draws to a close, we’re taking a look back to capture some of the highlights of the year before it disappears into the blur of previous years. One of the most exciting advances this year came from the … more »

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HLA Typing Workflow Uses Pippin Prep for Size Selection

Posted on December 14, 2016 by Alex

We’ve written before about the shift toward NGS-based technologies for the HLA typing market. HLA typing is used for everything from understanding autoimmune and infectious diseases to matching organ transplants to recipients. But the HLA locus really make scientists and … more »

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Moving to the Clinic: Interview with BC Cancer Agency’s Marco Marra

Posted on December 13, 2016 by Alex

Mendelspod’s recent interview with Marco Marra of the BC Cancer Agency and the University of British Columbia is well worth a listen. In the podcast, Marra describes his team’s use of genome and transcriptome sequencing for patients whose cancer is … more »

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Generation of Full-Length Class I Human Leukocyte Antigen Gene Consensus Sequences for Novel Allele Characterization

Posted on December 9, 2016 by Alex

December 2016 Authors: Peter M. Clark, Jamie L. Duke, Deborah Ferriola, Valia Bravo-Egana, Tunde Vago, Aniqa Hassan, Anna Papazoglou, and Dimitri Monos Info: Scientists from The Children’s Hospital of Philadelphia evaluated an NGS-based HLA typing kit from Omixon. They analyzed … more »

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Plasmids from Shiga Toxin-Producing Escherichia coli Strains with Rare Enterohemolysin Gene (ehxA) Subtypes Reveal Pathogenicity Potential and Display a Novel Evolutionary Path

Posted on December 9, 2016 by Alex

November 2016 Authors: Sandra C. Lorenz, Steven R. Monday, Maria Hoffmann, Markus Fischer and Julie A. Kase Info: Scientists from the US FDA and the University of Hamburg used PacBio sequencing to characterize plasmids associated with heightened virulence in Shiga … more »

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