The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity

December 2016

Samer G. Alam, Qiao Zhang, Nripesh Prasad, Yuan Li, Srikar Chamala, et al.

Researchers from the HudsonAlpha Institute, the University of Florida, and other institutions studied the role of rigidity in the extracellular matrix, finding that the regulation of certain genes relies on nuclear tension. They note that this is the first report of how the linker of nucleoskeleton and cytoskeleton complex alters gene expression throughout the genome. Pippin Prep was used to size-select small RNAs for building a microRNA library.

Scientific Reports 6, Article number: 38063 (2016)

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