Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

December 2016

Peter Ly, Levi S. Teitz, Dong H. Kim, Ofer Shoshani, Helen Skaletsky, Daniele Fachinetti, David C. Page, and Don W. Cleveland

Scientists report developing a strategy to examine what happens when chromosomes do not segregate properly. They found that missegregation into a micronucleus leads to a cascade of events affecting several cell cycles. PippinHT was used for size selection prior to paired-end sequencing on an Illumina HiSeq 2500 instrument.

Nature Cell Biology 19, 68–75 (2017)

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