Author Archives: Alex

How to CATCH Your Gene of Interest

Posted on May 18, 2017 by Alex

If you haven’t heard about CATCH by now, it’s time to catch up. Short for Cas9-assisted targeting of chromosome segments, CATCH comes from the lab of Yuval Ebenstein at Tel Aviv University and was first reported in this Nature Communications … more »

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Comparative Analysis of Ralstonia solanacearum Methylomes

Posted on May 10, 2017 by Alex

April 2017 Authors: Ivan Erill, Marina Puigvert, Ludovic Legrand, Rodrigo Guarischi-Sousa, et al. Info: Scientists report results of analyzing epigenetic patterns in two strains of a plant pathogen. They determined that methylation regulates virulence and adaptation to different host plants. … more »

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Tripartite species interaction: eukaryotic hosts suffer more from phage susceptible than from phage resistant bacteria

Posted on May 10, 2017 by Alex

April 2017 Authors: Carolin Wendling, Agnes Piecyk, Dominik Refardt, Cynthia Chibani, et al. Info: Scientists investigated the extent to which a bacterium’s susceptibility or resistance to prophages alters its own effect as a pathogen, finding that bacteria that were more … more »

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The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

Posted on April 30, 2017 by Alex

April 2017 Authors: Alexander Rialdi, Judd Hultquist, David Jimenez-Morales, Zuleyma Peralta, et al. Info: Scientists in New York and California teamed up to study the role of nuclear RNA exosomes in viral transcription, using influenza A. They found that the … more »

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Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals

Posted on April 26, 2017 by Alex

March 2017 Authors: Jan Weber, Richard Gibson, Lenka Sácká, Dmytro Strunin, et al. Info: In this publication, scientists describe an analysis of the rates of HIV progression in several patients. They determined that reduced viral replicative fitness appears to be … more »

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Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome

Posted on April 25, 2017 by Alex

March 2017 Authors: Warren Cheung, Xiaojian Shao, Andréanne Morin, Valérie Siroux, et al. Info: Researchers at McGill University and collaborating institutions used ChIP-seq to elucidate the effects of epigenetics and phenotype across the human genome. They analyzed more than 900 … more »

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Defining the diverse spectrum of inversions, complex structural variation, and chromothripsis in the morbid human genome

Posted on April 25, 2017 by Alex

March 2017 Authors: Ryan Collins, Harrison Brand, Claire Redin, Carrie Hanscom, et al. Info: Scientists at Harvard and other institutions sequenced nearly 700 individuals with autism spectrum disorder to build a comprehensive map of large structural variants. More than a … more »

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Asymmetric subgenome selection and cis-regulatory divergence during cotton domestication

Posted on April 25, 2017 by Alex

March 2017 Authors: Maojun Wang, Lili Tu, Min Lin, Zhongxu Lin, et al. Info: Scientists from China and the UK scanned the genomes of 352 varieties of cotton, both wild and domestic, to map variants associated with crop domestication throughout … more »

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Re-sequencing transgenic plants revealed rearrangements at T-DNA inserts, and integration of a short T-DNA fragment, but no increase of small mutations elsewhere

Posted on April 25, 2017 by Alex

March 2017 Authors: Henk J. Schouten, Henri vande Geest, Sofia Papadimitriou, Marian Bemer, Jan G. Schaart, Marinus J. M. Smulders, Gabino Sanchez Perez, Elio Schijlen Info: Scientists from Wageningen University and Research sequenced and analyzed several Arabidopsis thaliana plants to … more »

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On DNA Day, Let’s Stop the Slicing and Dicing

Posted on April 25, 2017 by Alex

Today is DNA Day, and we’re taking the opportunity to support the humane treatment of DNA. After all these years of harshly shearing these molecules and fragmenting them down to just a few hundred bases, can’t we agree that there … more »

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