The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

April 2017

Alexander Rialdi, Judd Hultquist, David Jimenez-Morales, Zuleyma Peralta, et al.

Scientists in New York and California teamed up to study the role of nuclear RNA exosomes in viral transcription, using influenza A. They found that the exosome coordinates transcription and that viral growth is suppressed when the RNA exosome’s activity is reduced. In the Illumina sequencing workflow, BluePippin was used to size-select PCR products.


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