Monthly Archives: April 2017

The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

Posted on April 30, 2017 by Alex

April 2017 Authors: Alexander Rialdi, Judd Hultquist, David Jimenez-Morales, Zuleyma Peralta, et al. Info: Scientists in New York and California teamed up to study the role of nuclear RNA exosomes in viral transcription, using influenza A. They found that the … more »

Posted in Citation | Tagged , | Comments Off on The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals

Posted on April 26, 2017 by Alex

March 2017 Authors: Jan Weber, Richard Gibson, Lenka Sácká, Dmytro Strunin, et al. Info: In this publication, scientists describe an analysis of the rates of HIV progression in several patients. They determined that reduced viral replicative fitness appears to be … more »

Posted in Citation | Tagged , | Comments Off on Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals

Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome

Posted on April 25, 2017 by Alex

March 2017 Authors: Warren Cheung, Xiaojian Shao, Andréanne Morin, Valérie Siroux, et al. Info: Researchers at McGill University and collaborating institutions used ChIP-seq to elucidate the effects of epigenetics and phenotype across the human genome. They analyzed more than 900 … more »

Posted in Citation | Tagged , , | Comments Off on Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome

Defining the diverse spectrum of inversions, complex structural variation, and chromothripsis in the morbid human genome

Posted on April 25, 2017 by Alex

March 2017 Authors: Ryan Collins, Harrison Brand, Claire Redin, Carrie Hanscom, et al. Info: Scientists at Harvard and other institutions sequenced nearly 700 individuals with autism spectrum disorder to build a comprehensive map of large structural variants. More than a … more »

Posted in Citation | Tagged , | Comments Off on Defining the diverse spectrum of inversions, complex structural variation, and chromothripsis in the morbid human genome

Asymmetric subgenome selection and cis-regulatory divergence during cotton domestication

Posted on April 25, 2017 by Alex

March 2017 Authors: Maojun Wang, Lili Tu, Min Lin, Zhongxu Lin, et al. Info: Scientists from China and the UK scanned the genomes of 352 varieties of cotton, both wild and domestic, to map variants associated with crop domestication throughout … more »

Posted in Citation | Tagged , | Comments Off on Asymmetric subgenome selection and cis-regulatory divergence during cotton domestication

Re-sequencing transgenic plants revealed rearrangements at T-DNA inserts, and integration of a short T-DNA fragment, but no increase of small mutations elsewhere

Posted on April 25, 2017 by Alex

March 2017 Authors: Henk J. Schouten, Henri vande Geest, Sofia Papadimitriou, Marian Bemer, Jan G. Schaart, Marinus J. M. Smulders, Gabino Sanchez Perez, Elio Schijlen Info: Scientists from Wageningen University and Research sequenced and analyzed several Arabidopsis thaliana plants to … more »

Posted in Citation | Tagged , | Comments Off on Re-sequencing transgenic plants revealed rearrangements at T-DNA inserts, and integration of a short T-DNA fragment, but no increase of small mutations elsewhere

On DNA Day, Let’s Stop the Slicing and Dicing

Posted on April 25, 2017 by Alex

Today is DNA Day, and we’re taking the opportunity to support the humane treatment of DNA. After all these years of harshly shearing these molecules and fragmenting them down to just a few hundred bases, can’t we agree that there … more »

Posted in Blog | Tagged | Comments Off on On DNA Day, Let’s Stop the Slicing and Dicing

At AACR, High-Profile Speakers and NGS Error Correction in the Spotlight

Posted on April 10, 2017 by Alex

Last week’s annual meeting of the American Association for Cancer Research offered some great perspectives on innovation in oncology, both in the clinic and in academic labs. We were particularly impressed by former Vice President Joe Biden’s update on the … more »

Posted in Blog | Tagged , , | Comments Off on At AACR, High-Profile Speakers and NGS Error Correction in the Spotlight