Tag Archives: BluePippin

Long-Read Isoform Sequencing Reveals a Hidden Complexity of the Transcriptional Landscape of Herpes Simplex Virus Type 1

Posted on June 12, 2017 by Alex

June 2017 Authors: Dóra Tombácz, Zsolt Csabai, Attila Szűcs, Zsolt Balázs, et al. Info: Scientists from Hungary and California conducted isoform sequencing with PacBio to analyze the transcriptome of herpes simplex virus type 1. They discovered dozens of previously unidentified … more »

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Comparative Analysis of Ralstonia solanacearum Methylomes

Posted on May 10, 2017 by Alex

April 2017 Authors: Ivan Erill, Marina Puigvert, Ludovic Legrand, Rodrigo Guarischi-Sousa, et al. Info: Scientists report results of analyzing epigenetic patterns in two strains of a plant pathogen. They determined that methylation regulates virulence and adaptation to different host plants. … more »

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Tripartite species interaction: eukaryotic hosts suffer more from phage susceptible than from phage resistant bacteria

Posted on May 10, 2017 by Alex

April 2017 Authors: Carolin Wendling, Agnes Piecyk, Dominik Refardt, Cynthia Chibani, et al. Info: Scientists investigated the extent to which a bacterium’s susceptibility or resistance to prophages alters its own effect as a pathogen, finding that bacteria that were more … more »

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The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

Posted on April 30, 2017 by Alex

April 2017 Authors: Alexander Rialdi, Judd Hultquist, David Jimenez-Morales, Zuleyma Peralta, et al. Info: Scientists in New York and California teamed up to study the role of nuclear RNA exosomes in viral transcription, using influenza A. They found that the … more »

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Defining the diverse spectrum of inversions, complex structural variation, and chromothripsis in the morbid human genome

Posted on April 25, 2017 by Alex

March 2017 Authors: Ryan Collins, Harrison Brand, Claire Redin, Carrie Hanscom, et al. Info: Scientists at Harvard and other institutions sequenced nearly 700 individuals with autism spectrum disorder to build a comprehensive map of large structural variants. More than a … more »

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Re-sequencing transgenic plants revealed rearrangements at T-DNA inserts, and integration of a short T-DNA fragment, but no increase of small mutations elsewhere

Posted on April 25, 2017 by Alex

March 2017 Authors: Henk J. Schouten, Henri vande Geest, Sofia Papadimitriou, Marian Bemer, Jan G. Schaart, Marinus J. M. Smulders, Gabino Sanchez Perez, Elio Schijlen Info: Scientists from Wageningen University and Research sequenced and analyzed several Arabidopsis thaliana plants to … more »

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Detecting DNA cytosine methylation using nanopore sequencing

Posted on March 25, 2017 by Alex

February 2017 Authors: Jared Simpson, Rachael Workman, PC Zuzarte, Matei David, LJ Dursi & Winston Timp Info: In this paper, scientists report developing algorithms to distinguish methylated from unmethylated DNA using the Oxford Nanopore MinION sequencer. They evaluated its performance … more »

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Evidence for concerted movement of nuclear and mitochondrial clines in a lizard hybrid zone

Posted on March 25, 2017 by Alex

February 2017 Authors: Adam D. Leaché, Jared A. Grummer, Rebecca B. Harris, and Ian K. Breckheimer Info: Scientists at the University of Washington analyzed samples collected over a 10-year period to better understand evolution of Sceloporus tristichus in a hybrid … more »

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Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution

Posted on March 25, 2017 by Alex

February 2017 Authors: Gavin G. Rutledge, Ulrike Böhme, Mandy Sanders, Adam J. Reid, et al. Info: In this paper, scientists generated a new reference genome and a manually curated draft assembly for two Plasmodium species. This effort made it possible … more »

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Subspecies delineation amid phenotypic, geographic and genetic discordance in a songbird

Posted on March 25, 2017 by Alex

February 2017 Authors: Jennifer Walsh, Irby J. Lovette, Virginia Winder, Chris S. Elphick, Brian J. Olsen, Gregory Shriver, and Adrienne I. Kovach Info: Scientists at Cornell University and other institutions analyzed sparrow populations using reduced-representation sequencing to understand the genetic … more »

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