Tag Archives: BluePippin

Creighton Lab Boosts Yield, Sequencing Efficiency with BluePippin

Posted on June 13, 2017 by Alex

At Creighton University in Omaha, Neb., Dr. Anna Selmecki’s lab explores various fungal species to understand genome instability, pathogenesis, and the acquisition of drug resistance. For these investigations, her team relies heavily on whole genome sequencing, using both the Illumina … more »

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Long-Read Isoform Sequencing Reveals a Hidden Complexity of the Transcriptional Landscape of Herpes Simplex Virus Type 1

Posted on June 12, 2017 by Alex

June 2017 Authors: Dóra Tombácz, Zsolt Csabai, Attila Szűcs, Zsolt Balázs, et al. Info: Scientists from Hungary and California conducted isoform sequencing with PacBio to analyze the transcriptome of herpes simplex virus type 1. They discovered dozens of previously unidentified … more »

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Comparative Analysis of Ralstonia solanacearum Methylomes

Posted on May 10, 2017 by Alex

April 2017 Authors: Ivan Erill, Marina Puigvert, Ludovic Legrand, Rodrigo Guarischi-Sousa, et al. Info: Scientists report results of analyzing epigenetic patterns in two strains of a plant pathogen. They determined that methylation regulates virulence and adaptation to different host plants. … more »

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Tripartite species interaction: eukaryotic hosts suffer more from phage susceptible than from phage resistant bacteria

Posted on May 10, 2017 by Alex

April 2017 Authors: Carolin Wendling, Agnes Piecyk, Dominik Refardt, Cynthia Chibani, et al. Info: Scientists investigated the extent to which a bacterium’s susceptibility or resistance to prophages alters its own effect as a pathogen, finding that bacteria that were more … more »

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The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity

Posted on April 30, 2017 by Alex

April 2017 Authors: Alexander Rialdi, Judd Hultquist, David Jimenez-Morales, Zuleyma Peralta, et al. Info: Scientists in New York and California teamed up to study the role of nuclear RNA exosomes in viral transcription, using influenza A. They found that the … more »

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Defining the diverse spectrum of inversions, complex structural variation, and chromothripsis in the morbid human genome

Posted on April 25, 2017 by Alex

March 2017 Authors: Ryan Collins, Harrison Brand, Claire Redin, Carrie Hanscom, et al. Info: Scientists at Harvard and other institutions sequenced nearly 700 individuals with autism spectrum disorder to build a comprehensive map of large structural variants. More than a … more »

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Re-sequencing transgenic plants revealed rearrangements at T-DNA inserts, and integration of a short T-DNA fragment, but no increase of small mutations elsewhere

Posted on April 25, 2017 by Alex

March 2017 Authors: Henk J. Schouten, Henri vande Geest, Sofia Papadimitriou, Marian Bemer, Jan G. Schaart, Marinus J. M. Smulders, Gabino Sanchez Perez, Elio Schijlen Info: Scientists from Wageningen University and Research sequenced and analyzed several Arabidopsis thaliana plants to … more »

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Detecting DNA cytosine methylation using nanopore sequencing

Posted on March 25, 2017 by Alex

February 2017 Authors: Jared Simpson, Rachael Workman, PC Zuzarte, Matei David, LJ Dursi & Winston Timp Info: In this paper, scientists report developing algorithms to distinguish methylated from unmethylated DNA using the Oxford Nanopore MinION sequencer. They evaluated its performance … more »

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Evidence for concerted movement of nuclear and mitochondrial clines in a lizard hybrid zone

Posted on March 25, 2017 by Alex

February 2017 Authors: Adam D. Leaché, Jared A. Grummer, Rebecca B. Harris, and Ian K. Breckheimer Info: Scientists at the University of Washington analyzed samples collected over a 10-year period to better understand evolution of Sceloporus tristichus in a hybrid … more »

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Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution

Posted on March 25, 2017 by Alex

February 2017 Authors: Gavin G. Rutledge, Ulrike Böhme, Mandy Sanders, Adam J. Reid, et al. Info: In this paper, scientists generated a new reference genome and a manually curated draft assembly for two Plasmodium species. This effort made it possible … more »

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