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Monthly Archives: January 2017
Podcast: Structural Variation Pioneer Evan Eichler on Moving Toward the Clinic
We’ve been big fans of the structural variation work coming out of Evan Eichler’s University of Washington lab for years, so when he was the subject of a Mendelspod interview, we couldn’t wait to listen. If you missed the podcast, … more »
RAD-seq, High-Pass Sizing in Sunny San Diego
We are shaking off this northeast winter and heading out to San Diego for the 25th annual International Plant and Animal Genome meeting! This event is always a great way to kick off the year, surrounded by cutting-edge science and … more »
Targeted capture and sequencing of gene-sized DNA molecules
December 2016 Authors: Michael Giolai, Pirita Paajanen, Walter Verweij, Lawrence Percival-Alwyn, et al. Info: Scientists adapted the RenSeq capture method for long-read PacBio sequencing, optimizing the method through improved shearing, size selection, and PCR amplification. They used SageELF extensively to … more »
Defining an olfactory receptor function in airway smooth muscle cells
December 2016 Authors: William H. Aisenberg, Jessie Huang, Wanqu Zhu, Premraj Rajkumar, et al. Info: Scientists at Johns Hopkins University, Rutgers, and other institutions teamed up to study receptors in airway smooth muscle cells that appear to play a role … more »
Posted in Citation
Tagged HiSeq, Pippin Prep, RNA-seq
Comments Off on Defining an olfactory receptor function in airway smooth muscle cells
The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity
December 2016 Authors: Samer G. Alam, Qiao Zhang, Nripesh Prasad, Yuan Li, Srikar Chamala, et al. Info: Researchers from the HudsonAlpha Institute, the University of Florida, and other institutions studied the role of rigidity in the extracellular matrix, finding that … more »
Posted in Citation
Tagged microRNA, Pippin Prep
Comments Off on The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining
December 2016 Authors: Peter Ly, Levi S. Teitz, Dong H. Kim, Ofer Shoshani, Helen Skaletsky, Daniele Fachinetti, David C. Page, and Don W. Cleveland Info: Scientists report developing a strategy to examine what happens when chromosomes do not segregate properly. … more »
Susceptibility to Aminoglycosides and Distribution of aph and aac(3)-XI Genes among Corynebacterium striatum Clinical Isolates
December 2016 Authors: Jesús Navas, Marta Fernández-Martínez, Carlos Salas, María Eliecer Cano, Luis Martínez-Martínez Info: Scientists in Spain analyzed several strains of the pathogen Corynebacterium striatum and found that many were resistant to drugs most commonly used to treat these … more »
Posted in Citation
Tagged BluePippin, MiSeq
Comments Off on Susceptibility to Aminoglycosides and Distribution of aph and aac(3)-XI Genes among Corynebacterium striatum Clinical Isolates
Single-Molecule Sequencing (PacBio) of the Staphylococcuscapitis NRCS-A Clone Reveals the Basis of Multidrug Resistance and Adaptation to the Neonatal Intensive Care Unit Environment
December 2016 Authors: Patrícia MartinsSimões, HajarLemriss, YannDumont, SanâaLemriss, et al. Info: Scientists in France and Morocco fully sequenced the genome and accessory genome of a Staphylococcus capitis clone that has proven resistant to many drugs and is particularly detrimental to … more »
Posted in Citation
Tagged BluePippin, PacBio
Comments Off on Single-Molecule Sequencing (PacBio) of the Staphylococcuscapitis NRCS-A Clone Reveals the Basis of Multidrug Resistance and Adaptation to the Neonatal Intensive Care Unit Environment