Author Archives: Alex

A spontaneous complex structural variant in rcan-1 increases exploratory behavior and laboratory fitness of Caenorhabditis elegans

Posted on March 3, 2020 by Alex

February 2020 Authors: Yuehui Zhao, Lijiang Long, Jason Wan, Shweta Biliya, Shannon C. Brady, Daehan Lee, Akinade Ojemakinde, Erik C. Andersen, Fredrik O. Vannberg, Hang Lu, Patrick T. McGrath Info: Researchers studying genetic adaptive changes using C. elegans recombinant inbred … more »

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Amplification-free long read sequencing reveals unforeseen CRISPR-Cas9 off-target activity

Posted on February 8, 2020 by Alex

February 2020 Authors: Ida Höijer, Josefin Johansson, Sanna Gudmundsson, Chen-Shan Chin, Ignas Bunikis, Susana Häggqvist, Anastasia Emmanouilidou, Maria Wilbe, Marcel den Hoed, Marie-Louise Bondeson, Lars Feuk, Ulf Gyllensten, Adam Ameur Info: In this preprint, the authors propose a method for … more »

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Capture of complete ciliate chromosomes in single sequencing reads reveals widespread chromosome isoforms

Posted on January 5, 2020 by Alex

December 2019 Authors: Kelsi A. Lindblad, Jananan S. Pathmanathan, Sandrine Moreira, John R. Bracht, Robert P. Sebra, Elizabeth R. Hutton & Laura F. Landweber Info: Researchers sequenced the whole genome of Oxytricha trifallax, a model protozoan ciliate, using long read … more »

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SageHLS sample prep for ultra-long Nanopore Sequencing at NextOmics/GrandOmics

Posted on November 22, 2019 by Alex

NextOmics/GrandOmics is the largest third-generation sequencing service company in China. The NextOmics division focuses on animal, plant and bacterial genome sequencing, while GrandOmics focuses on human genome sequencing. GrandOmics became the first certified PromethIon service provider in China in June, … more »

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Comparison of mitochondrial DNA variants detection using short- and long-read sequencing

Posted on August 19, 2019 by Alex

August 2019 Authors: Ahmed N. Alkanaq, Kohei Hamanaka, Futoshi Sekiguchi, Masataka Taguri, Atsushi Takata, Noriko Miyake, Satoko Miyatake, Takeshi Mizuguchi, Naomichi Matsumot Info: The genotypes of mitochondrial DNA variants are compared using both short-read (Illumina Hi-SeqX10) and long-read (PacBio Sequel) … more »

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Ingestible Osmotic Pill for In‐vivo Sampling of Gut Microbiome

Posted on July 30, 2019 by Alex

July 2019 Authors: Hojatollah Rezaei Nejad, Bruno C. M. Oliveira, Aydin Sadeqi, Amin Dehkharghani, Ivanela Kondova Jan A. M. Langermans, Jeffrey S. Guasto, Saul Tzipori, Giovanni Widmer, Sameer R. Sonkusale Info: From Engineering and Nano Labs at Tufts University, and … more »

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Distinct Profiles of Cell-Free MicroRNAs in Plasma of Veterans with Post-Traumatic Stress Disorder

Posted on July 3, 2019 by Alex

July 2019 Authors: Min Young Lee, David Baxter, Kelsey Scherler , Taek-Kyun Kim, Xiaogang Wu , Duna Abu-Amara, Janine Flory, Rachel Yehuda, Charles Marma, Marti Jett, Inyoul Lee, Kai Wang, and Leroy Hood Info: Researchers report on studies that profile … more »

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Structural variants identified by Oxford Nanopore PromethION sequencing of the human genome

Posted on June 28, 2019 by Alex

June 2019 Authors: De Coster Wouter, De Rijk Peter, De Roeck Arne, De Pooter Tim, D’Hert Svenn, Strazisar Mojca, Kristel Sleegers and Van Broeckhoven Christine Info: Researchers from VIB Center for Molecular Neurology, Antwerp Belgium and University of Antwerp assess … more »

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Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the differentiation of embryonic stem cells towards pancreatic lineage and pancreatic beta cell function

Posted on June 28, 2019 by Alex

May 2019 Authors: John A. Kubi, Andy C.H. Chen, Sze Wan Fong, Keng Po Lai, Chris K.C. Wong, William S.B. Yeung, Kai Fai Lee, Yin Lau Lee Info: From the University of Hong Kong and Hong Kong Baptist University, this … more »

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Sage Science Receives $1.8M Grant from NHGRI to Automate the HLS-CATCH Targeted DNA Sample Preparation Method

Posted on May 21, 2019 by Alex

BEVERLY, Mass. — May 21, 2019— Sage Science, a developer of products for improving sample preparation processes in life science applications, today announced the award of $1.8M from the National Human Genome Research Institute. The grant funds a two-year program … more »

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