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Tag Archives: PippinHT
New Protocol: Analyze Small Extracellular RNAs with PippinHT
Good protocols are the currency of any lab. If your research involves working with small RNAs, be sure to check out this carefully documented protocol published in Extracellular RNA, part of Springer Nature’s Methods in Molecular Biology book series. The protocol … more »
Improving saliva shotgun metagenomics by chemical host DNA depletion
February 2018 Authors: Clarisse Marotz, Jon Sanders, Cristal Zuniga, Livia Zaramela, Rob Knight, and Karsten Zengler Info: Scientists from the University of California, San Diego, developed and evaluated a new protocol for enriching microbial DNA collected from fresh and frozen … more »
Study protocol: rationale and design of the community-based prospective cohort study of kidney function and diabetes in rural New Mexico, the COMPASS study
February 2018 Authors: Antonin Jaros, Hafiz Sroya, Venita Wolfe, Vikas Ghai, et al. Info: Scientists report design and launch of the COMPASS study, a prospective, longitudinal cohort in rural New Mexico aimed at better understanding diabetic chronic kidney disease and … more »
Ribonuclease Inhibitor 1 regulates erythropoiesis by controlling GATA1 translation
February 2018 Authors: Vijaykumar Chennupati, Diogo Veiga, Kendle Maslowski, Nicola Andina, et al. Info: Scientists studying the ribonuclease inhibitor protein found that it controls translation of GATA1 and thereby regulates erythropoiesis, helping to explain anemia-associated diseases caused by mutations in … more »
Oligomeric proanthocyanidins (OPCs) target cancer stem-like cells and suppress tumor organoid formation in colorectal cancer
February 2018 Authors: Shusuke Toden, Preethi Ravindranathan, Jinghua Gu, Jacob Cardenas, Madelaine Yuchang & Ajay Goel Info: Scientists from Baylor University Medical Center studied the chemoprotective role of oligomeric proanthocyanidins, finding that they inhibited cellular proliferation and spurred apoptosis. RNA … more »
Identification of a precursor processing protease from the spider Cupiennius saleiessential for venom neurotoxin maturation
February 2018 Authors: Nicolas Langenegger, Dominique Koua, Stefan Schürch, Manfred Heller, Wolfgang Nentwig and Lucia Kuhn-Nentwig Info: In this paper, scientists from the University of Bern and collaborators report the identification and purification of a protease that’s an important neurotoxin … more »
A Look Back at 2017
As we start to make lists of New Year’s resolutions (with bets on how long they’ll last), it’s the perfect time for a moment to absorb the themes and highlights of 2017. In our corner of the world, that means … more »
Genome-wide DNA methylation profiling using the methylation-dependent restriction enzyme LpnPI
December 2017 Authors: Ruben Boers, Joachim Boers, Bas de Hoon, Christel Kockx, et al. Info: Scientists at Erasmus Medical Center determined that analysis of genome-wide methylation is challenging when fragment sizes are too small and that better epigenetic results are … more »
Mapping and phasing of structural variation in patient genomes using nanopore sequencing
November 2017 Authors: Mircea Cretu Stancu, Markus van Roosmalen, Ivo Renkens, Marleen Nieboer, et al. Info: Scientists used the Oxford MinION nanopore sequencer with a novel pipeline, NanoSV, to detect structural variants from the genomes of two patients. They found … more »
Posted in Citation
Tagged oxford nanopore, PippinHT
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Circulating Tumor DNA Easier to Spot with Size Selection
A bioRxiv preprint from scientists at Cancer Research UK and Cambridge University Hospitals offers a look at how DNA size selection can be used to enhance results of circulating tumor DNA studies. Their analysis indicates that adding a simple sizing … more »
Posted in Blog
Tagged cell-free DNA, ctDNA, PippinHT
Comments Off on Circulating Tumor DNA Easier to Spot with Size Selection