Tag Archives: PippinHT

Study protocol: rationale and design of the community-based prospective cohort study of kidney function and diabetes in rural New Mexico, the COMPASS study

Posted on March 12, 2018 by Alex

February 2018 Authors: Antonin Jaros, Hafiz Sroya, Venita Wolfe, Vikas Ghai, et al. Info: Scientists report design and launch of the COMPASS study, a prospective, longitudinal cohort in rural New Mexico aimed at better understanding diabetic chronic kidney disease and … more »

Posted in Citation | Tagged , | Comments Off on Study protocol: rationale and design of the community-based prospective cohort study of kidney function and diabetes in rural New Mexico, the COMPASS study

Ribonuclease Inhibitor 1 regulates erythropoiesis by controlling GATA1 translation

Posted on March 12, 2018 by Alex

February 2018 Authors: Vijaykumar Chennupati, Diogo Veiga, Kendle Maslowski, Nicola Andina, et al. Info: Scientists studying the ribonuclease inhibitor protein found that it controls translation of GATA1 and thereby regulates erythropoiesis, helping to explain anemia-associated diseases caused by mutations in … more »

Posted in Citation | Tagged | Comments Off on Ribonuclease Inhibitor 1 regulates erythropoiesis by controlling GATA1 translation

Oligomeric proanthocyanidins (OPCs) target cancer stem-like cells and suppress tumor organoid formation in colorectal cancer

Posted on March 12, 2018 by Alex

February 2018 Authors: Shusuke Toden, Preethi Ravindranathan, Jinghua Gu, Jacob Cardenas, Madelaine Yuchang & Ajay Goel Info: Scientists from Baylor University Medical Center studied the chemoprotective role of oligomeric proanthocyanidins, finding that they inhibited cellular proliferation and spurred apoptosis. RNA … more »

Posted in Citation | Tagged | Comments Off on Oligomeric proanthocyanidins (OPCs) target cancer stem-like cells and suppress tumor organoid formation in colorectal cancer

Identification of a precursor processing protease from the spider Cupiennius saleiessential for venom neurotoxin maturation

Posted on March 12, 2018 by Alex

February 2018 Authors: Nicolas Langenegger, Dominique Koua, Stefan Schürch, Manfred Heller, Wolfgang Nentwig and Lucia Kuhn-Nentwig Info: In this paper, scientists from the University of Bern and collaborators report the identification and purification of a protease that’s an important neurotoxin … more »

Posted in Citation | Tagged | Comments Off on Identification of a precursor processing protease from the spider Cupiennius saleiessential for venom neurotoxin maturation

A Look Back at 2017

Posted on December 18, 2017 by Alex

As we start to make lists of New Year’s resolutions (with bets on how long they’ll last), it’s the perfect time for a moment to absorb the themes and highlights of 2017. In our corner of the world, that means … more »

Posted in Blog | Tagged , , , , | Comments Off on A Look Back at 2017

Genome-wide DNA methylation profiling using the methylation-dependent restriction enzyme LpnPI

Posted on December 10, 2017 by Alex

December 2017 Authors: Ruben Boers, Joachim Boers, Bas de Hoon, Christel Kockx, et al. Info: Scientists at Erasmus Medical Center determined that analysis of genome-wide methylation is challenging when fragment sizes are too small and that better epigenetic results are … more »

Posted in Citation | Tagged , | Comments Off on Genome-wide DNA methylation profiling using the methylation-dependent restriction enzyme LpnPI

Mapping and phasing of structural variation in patient genomes using nanopore sequencing

Posted on November 18, 2017 by Alex

November 2017 Authors: Mircea Cretu Stancu, Markus van Roosmalen, Ivo Renkens, Marleen Nieboer, et al. Info: Scientists used the Oxford MinION nanopore sequencer with a novel pipeline, NanoSV, to detect structural variants from the genomes of two patients. They found … more »

Posted in Citation | Tagged , | Comments Off on Mapping and phasing of structural variation in patient genomes using nanopore sequencing

Circulating Tumor DNA Easier to Spot with Size Selection

Posted on October 10, 2017 by Alex

A bioRxiv preprint from scientists at Cancer Research UK and Cambridge University Hospitals offers a look at how DNA size selection can be used to enhance results of circulating tumor DNA studies. Their analysis indicates that adding a simple sizing … more »

Posted in Blog | Tagged , , | Comments Off on Circulating Tumor DNA Easier to Spot with Size Selection

Micro RNA’s (miRNA’s) may help explain expression of multiple genes in Alzheimer’s Frontal Cortex

Posted on September 20, 2017 by Alex

September 2017 Authors: James Bennett and Paula Keeney Info: Scientists from Neurodegeneration Therapeutics used RNA-seq to compare microRNAs found in Alzheimer’s brain samples and controls. They identified 55 up-regulated genes and 191 down-regulated genes in the Alzheimer’s samples. PippinHT was … more »

Posted in Citation | Tagged , | Comments Off on Micro RNA’s (miRNA’s) may help explain expression of multiple genes in Alzheimer’s Frontal Cortex

A SINE insertion in ATP1B2 in Belgian Shepherd dogs affected by spongy degeneration with cerebellar ataxia (SDCA2)

Posted on August 18, 2017 by Alex

August 2017 Authors: Nico Mauri, Miriam Kleiter, Elisabeth Dietschi, Michael Leschnik, et al. Info: Scientists in Europe and the US studied the genetic basis for a neurodegenerative disorder in dogs. Through whole genome sequencing data, they found a SINE insertion … more »

Posted in Citation | Tagged | Comments Off on A SINE insertion in ATP1B2 in Belgian Shepherd dogs affected by spongy degeneration with cerebellar ataxia (SDCA2)