Tag Archives: HLS

Resolving the 22q11.2 deletion using CTLR-Seq reveals chromosomal rearrangement mechanisms and individual variance in breakpoints

Posted on July 21, 2024 by Alex

July 2024 Authors: Bo Zhou, Carolin Purmann, Hanmin Guo, GiWon Shin, Yiling Huang, Reenal Pattni, Qingxi Meng, Stephanie U. Greer, Tanmoy Roychowdhuryg, Raegan N. Wood, Marcus Ho, Heinrich zu Dohna, Alexej Abyzov, Joachim F. Hallmayer, Wing H. Wong, Hanlee P. … more »

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CTLR-Seq Protocol

Posted on July 20, 2024 by Alex

July 2024 Authors: Bo Zhou, GiWon Shin,Yiling Huang, Raegan N. Wood, Hanlee P. Ji, Alexander E. Urban Abstract: “We developed a generally applicable method CRISPR/Cas9-targeted long read sequencing (CTLR-Seq) to resolve, haplotype-specifically, and at base-pair resolution, large, complex, and highly … more »

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High-quality Arabidopsis thaliana Genome Assembly with Nanopore and HiFi Long Reads

Posted on September 15, 2021 by Alex

September 2021 Authors: Bo Wang, Xiaofei Yang, Yanyan Jia, Yu Xu, Peng Jia, Ningxin Dang, Songbo Wang, Tun Xu, Xixi Zhao, Shenghan Gao, Quanbin Dong, Kai Ye Info: The authors report on a high quality genome assembly of the model … more »

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At AGBT, Scientists Offer Data on Size Selection for HMW DNA

Posted on February 13, 2018 by Alex

Even Orlando’s sky-high humidity can’t get us down during a fast-paced AGBT meeting where size selection and HMW DNA have been front and center since the opening session. Last night we enjoyed a plenary talk from Ami Bhatt, a scientist … more »

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Q&A: How SageHLS Brings Back the ‘Lost Art’ of HMW DNA Prep

Posted on March 2, 2017 by Alex

Chris Boles is Chief Scientific Officer of Sage Science, where he’s been helping the R&D team develop the new SageHLS (that’s short for HMW Library System), a platform designed to rapidly purify high molecular weight DNA directly from samples. We … more »

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The Darling of AGBT: HMW DNA

Posted on February 20, 2017 by Alex

The Sage Science team had a blast at this year’s AGBT conference in Hollywood, Fla. We thoroughly enjoyed the parties, the beach, and especially the excellent talks. We’d like to thank all of the attendees who made their way to … more »

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Calling All Technophiles: Time for AGBT!

Posted on February 9, 2017 by Alex

The Sage Science team is casting off the shackles of winter and gearing up for a trip to sunny Florida for the annual Advances in Genome Biology and Technology meeting. We look forward to this conference each year — it’s … more »

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RAD-seq, High-Pass Sizing in Sunny San Diego

Posted on January 13, 2017 by Alex

We are shaking off this northeast winter and heading out to San Diego for the 25th annual International Plant and Animal Genome meeting! This event is always a great way to kick off the year, surrounded by cutting-edge science and … more »

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ASHG 2016: Structural Variants, Mega Databases, and the Best-Ever Human Genome

Posted on October 28, 2016 by Alex

The Sage Science team enjoyed our trip across the border to Canada for the annual meeting of the American Society of Human Genetics this month. Vancouver was practically teeming with genome scientists! Many presentations this year featured results generated by … more »

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Get a Glimpse of the New HLS Instrument at ASHG 2016

Posted on October 18, 2016 by Alex

The Sage Science team is heading to Vancouver this week for the annual meeting of the American Society of Human Genetics. ASHG is the biggest genomics meeting we attend each year, and it never fails to deliver on its promise … more »

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