DNA methylation is required for the control of stem cell differentiation in the small intestine

March 2014

Karyn L. Sheaffer, Rinho Kim, Reina Aoki, Ellen N. Elliott, Jonathan Schug, Lukas Burger, Dirk Schubeler, and Klaus H. Kaestner

Scientists in Switzerland and Pennsylvania sought to understand the role of methylation in stem cell-directed regeneration of the intestinal epithelium in mice. They size selected for 300-600 bp DNA fragments and sequenced them with Illumina. Results indicate that losing DNA methylation at particular enhancer sites delayed stem cell differentiation and led to unusual gene expression, both of which could contribute to development of cancer.

Genes Dev. 2014 28: 652-664


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