Transmission of microRNA antimiRs to mouse offspring via the maternal-placental-fetal unit

March 2018

Jonas Hönig, Ivana Mižíková, Claudio Nardiello, David Emanuel Surate Solaligue, et al.


In Germany, researchers delivered microRNA inhibitors to pregnant mice, finding that the antimiRs were then detectable in offspring, where they caused fewer off-target effects compared to direct injection of antimiRs into mouse pups. This approach could make it easier to study the effects of microRNAs during pregnancy and early postnatal development. For this project, the team used PippinHT to size-select RNA pools with a target size of 154 bp.


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