Full-length mRNA sequencing uncovers a widespread coupling between transcription initiation and mRNA processing

March 2018

Seyed Yahya Anvar, Guy Allard, Elizabeth Tseng, Gloria Sheynkman, et al.

Researchers from Leiden University Medical Center and other institutions studied the relationships between transcription initiation and splicing and polyadenylation events in breast cancer cells and several types of human tissue. They found that there are still unresolved mechanisms governing transcription. The team used SageELF to create size-based fractions for cDNA libraries prior to sequencing with PacBio.

Genome Biology 2018 19:46
doi: 10.1186/s13059-018-1418-0

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