QseC inhibition as an antivirulence approach for colitis-associated bacteria

January 2017

Michelle G. Rooks, Patrick Veiga, Analise Z. Reeves, Sydney Lavoie, et al.

In this paper, scientists from Harvard and other institutions describe a study of quorum-sensing regulators in E. coli as a possible means of reducing intestinal inflammation in models of inflammatory bowel disease. They found that inactivating these regulators reduced virulence of a particular E. coli strain. As part of the project, the team used Pippin Prep to size-select pooled amplicons prior to sequencing on the Illumina MiSeq platform.

PNAS January 3, 2017 vol. 114 no. 1 142-147

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