Placental miR-1301 is dysregulated in early-onset preeclampsia and inversely correlated with maternal circulating leptin

September 2014

M.S. Weedon-Fekjær, Y. Sheng, M. Sugulle, G.M. Johnsen, F. Herse, C.W. Redman, R. Lyle, R. Dechend, A.C. Staff

Scientists from Norway, the UK, and Germany used sequenced small RNAs in placenta from patients with and without preeclampsia to determine whether microRNAs have a regulatory role in this condition. They found that miRNAs may be regulating the leptin gene, which affects both maternal blood pressure and newborn weight percentile. cDNA was size selected using Pippin Prep.


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