Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn

September 2011

Laura G. Reinholdt, Yueming Ding, Griffith T. Gilbert, Anne Czechanski, Jeffrey P. Solzak, Randall J. Roper, Mark T. Johnson, Leah Rae Donahue, Cathleen Lutz, Muriel T. Davisson

Illumina PE libraries were constructed and size selected at 400bp “tight” setting on Pippin Prep prior to enrichment PCR and hybridization capture for genomic region surrounding the Down syndrome locus in mouse, to identify rearrangements in a much-studied Down’s syndrome model strain.

Mamm Genome (2011) 22:685–691

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