Genetic Basis for the Biosynthesis of the Pharmaceutically Important Class of Epoxyketone Proteasome Inhibitors

October 2013

Michelle Schorn, Judith Zettler, Joseph P. Noel, Pieter C. Dorrestein, Bradley S. Moore, and Leonard Kaysser

Collaborators in the U.S. and Germany report on the genetic pathway for the production of epoxyketone proteasome inhibitors, used as anti-cancer therapeutic agents, in bacterial strains. The Pippin Prep was used to size select DNA prior to Ion Torrent sequencing.

ACS Chem. Biol. 2014, 9, 301−309


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