Design and synthesis of a minimal bacterial genome

March 2016

Clyde A. Hutchison III, Ray-Yuan Chuang, Vladimir N. Noskov, et al.


Scientists from the J. Craig Venter Institute and other institutes systematically stripped out genes from the Mycoplasma mycoides genome until they were down to the 473 genes necessary for the organism’s survival. They used BluePippin with the PacBio RS II for de novo assembly of the artificial genome.

Science 25 Mar 2016: Vol. 351, Issue 6280
DOI: 10.1126/science.aad6253

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