Very Short Mitochondrial DNA Fragments and Heteroplasmy in Human Plasma

November 2016

Ruoyu Zhang, Kiichi Nakahira, Xiaoxian Guo, Augustine M.K. Choi & Zhenglong Gu

Scientists at Cornell University studied cell-free mitochondrial DNA found in plasma samples collected from sepsis patients. Along the way, they optimized sample prep protocols for short DNA fragments, producing nearly 12 times more fragments in the target size range than standard protocols. They used BluePippin to enrich libraries for fragments of 150 bp to 190 bp.

Scientific Reports 6, Article number: 36097 (2016)

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