Pitfalls of haplotype phasing from amplicon-based long-read sequencing

February 2016

Thomas W. Laver, Richard C. Caswell, Karen A. Moore, Jeremie Poschmann, Matthew B. Johnson, Martina M. Owens, Sian Ellard, Konrad H. Paszkiewicz & Michael N. Weedon

University of Exeter researchers used long-range PCR and long-read sequencing to phase genetic variants separated by 9 Kb, comparing results from the PacBio and Oxford Nanopore sequencing systems. BluePippin was used for size selection of the PacBio 20 Kb library.

Scientific Reports 6, Article number: 21746 (2016)

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