Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate

February 2016


Ingrid C. Rulifson, Ping Cao, Li Miao, David Kopecky, Linda Huang, Ryan D. White, Kim Samayoa, Jonitha Gardner, Xiaosu Wu, Kui Chen, Trace Tsuruda, Oliver Homann, Helene Baribault, Harvey Yamane, Tim Carlson, Jed Wiltzius, Yang Li

Researchers from Amgen report on a proteolytic enzyme, BACE2, that could potentially have a therapeutic use for treatment of pancreatic amyloid formation caused by Type-2 diabetes. Illumina RNA-seq, with Pippin size selection, was used to test whether BACE would modulate its target proteins in a cellular setting.

PLoS ONE 11(2): e0147254

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