Pharmacologic activation of estrogen receptor β increases mitochondrial function, energy expenditure, and brown adipose tissue

January 2017

Authors:
Suriyan Ponnusamy, Quynh T. Tran, Innocence Harvey, Heather S. Smallwood, et al.

Info:
Scientists in Memphis, Tenn., studied obesity in mice, finding that estrogen receptor β and its ligands had a strong anti-obesity effect, reducing weight gain and adiposity in mice without any changes to activity levels or food intake. This could indicate a new opportunity for safe anti-obesity therapeutics in humans. For this project, Pippin Prep was used for library sizing prior to sequencing on an Ion Torrent Proton.

Citation:
The FASEB Journal vol. 31 no. 1 266-281
doi:10.1096/fj.201600787RR

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