Improved Multiple Displacement Amplification (iMDA) and Ultraclean Reagents

June 2014

S Timothy Motley, John M Picuri, Chris D Crowder, Jeremiah J Minich, Steven A Hofstadler and Mark W Eshoo

In this methods paper, researchers from Ibis Biosciences report a superior whole-genome amplification protocol that can be used with very small samples to yield enough DNA for sequencing. Their method showed better efficiency and accuracy than commercially available whole-genome amplification kits for low-input samples. Testing was done on the PGM, and Pippin Prep was used for size selection.

BMC Genomics 2014, 15:443


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