Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification

January 2014

Peter Tessarz, Helena Santos-Rosa, Sam C. Robson, Kathrine B. Sylvestersen, Christopher J. Nelson1, Michael L. Nielsen and Tony Kouzarides

The authors describe a new class of histone modification, methylation of glutamine, occurring on yeast histone H2A. The data suggests that this is the first histone epigenetic mark dedicated to a specific RNA polymerase. Pippin Prep was used to size select ChIP seq libraries prior to Illumina sequencing.

Nature, 505 (23) January 2014

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