Evolution of hypervirulence by a MRSA clone through acquisition of a transposable element

July 2014

Meredith A. Benson, Elizabeth A. Ohneck, Chanelle Ryan, Francis Alonzo III, Hannah Smith, Apurva Narechania, Sergios-Orestis Kolokotronis, Sarah W. Satola, Anne-Catrin Uhlemann, Robert Sebra, Gintaras Deikus, Bo Shopsin, Paul J. Planet and Victor J. Torres

Scientists in Georgia and New York used MiSeq and PacBio sequencers to analyze a hypervirulent strain of methicillin-resistant Staphylococcus aureus, finding a novel evolutionary event. The project offers new findings about evolutionary strategies that have an impact on virulence. The team used BluePippin for to remove fragments smaller than 7 Kb from their libraries prior to sequencing on the PacBio instrument.

Molecular Microbiology (2014) 93(4), 664–681


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