DSBCapture: in situ capture and sequencing of DNA breaks

August 2016


Stefanie V Lensing, Giovanni Marsico, Robert Hänsel-Hertsch, Enid Y Lam, David Tannahill & Shankar Balasubramanian

Scientists at Cancer Research UK developed and validated a new sequencing-based protocol to spot double-stranded DNA breaks in situ; these regions are important for study because they contribute to mutations and chromosomal rearrangements. The method includes performing size selection on a BluePippin prior to sequencing

Nature Methods (2016)

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