Discovery of Novel Rhabdoviruses in the Blood of Healthy Individuals from West Africa

March 2015

Matthew H Stremlau, Kristian G Andersen, Onikepe A Folarin, Jessica N Grove, Ikponmwonsa Odia, Philomena E Ehiane, Omowunmi Omoniwa, Omigie Omoregie, Pan-Pan Jiang, Nathan L Yozwiak, Christian B Matranga, Xiao Yang, Stephen K Gire, Sarah Winnicki, Ridhi Tariyal, Stephen F Schaffner, Peter O Okokhere, Sylvanus Okogbenin, George O Akpede, Danny A. Asogun, Dennis E. Agbonlahor, Peter J Walker, Robert B Tesh, Joshua Z Levin, Robert F Garry, Pardis C Sabeti, Christian T Happi

In this PLOS Neglected Tropical Diseases paper, researchers utilized next-generation sequencing to identify RNA viruses in the blood of 195 patients with unexplained acute febrile illness and compared them with those found in 328 apparently healthy control individuals, all from communities in southeastern Nigeria. The researchers suggest that human infection with rhabdoviruses might be common. Carrier RNA was removed after cDNA synthesis using Pippin Prep size selection.

PLoS Negl Trop Dis
9(3): e0003631. doi:10.1371/journal.pntd.0003631

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