Category Archives: Blog

Preprint Roundup: Long-Read Sequencing, ddRAD-seq, and a New Look at Viruses

Posted on November 27, 2017 by Alex

We always keep our eyes peeled for interesting new research from scientists using Sage Science automated DNA size selection instruments, and several recent preprints caught our attention. Here’s a look: Nanopore Sequencing Reveals High-Resolution Structural Variation in the Cancer Genome … more »

Posted in Blog | Tagged , , , | Comments Off on Preprint Roundup: Long-Read Sequencing, ddRAD-seq, and a New Look at Viruses

Podcast: Genome Assembly Guru Deanna Church on Linked Reads and Single-Cell Genomics

Posted on October 31, 2017 by Alex

If you’ve ever relied on the human reference genome, don’t miss this podcast with assembly pioneer Deanna Church. Mendelspod’s Theral Timpson interviews the genome informatics expert who made her name as an integral part of the reference project at the … more »

Posted in Blog | Tagged , | Comments Off on Podcast: Genome Assembly Guru Deanna Church on Linked Reads and Single-Cell Genomics

Tracking Chikungunya: New Study Traces Outbreak Path

Posted on October 25, 2017 by Alex

A team of scientists in Brazil, along with collaborators in the U.S. and Europe, used diagnostics and metagenomic sequencing to reconstruct the transmission path of a recent outbreak of chikungunya virus in Maceió. We were honored to donate some lab … more »

Posted in Blog | Tagged , , | Comments Off on Tracking Chikungunya: New Study Traces Outbreak Path

Large Variants and Even Larger Cohorts: Recapping ASHG

Posted on October 23, 2017 by Alex

We had a blast as ASHG last week, and wanted to thank all the attendees who stopped by our booth. We were delighted to meet you all! If you couldn’t make it to ASHG, a couple of running themes dominated … more »

Posted in Blog | Tagged | Comments Off on Large Variants and Even Larger Cohorts: Recapping ASHG

ASHG 2017: Big Studies, Big Names, and Big DNA

Posted on October 12, 2017 by Alex

We can’t wait for the annual meeting of the American Society of Human Genetics next week! The Sage Science team will be heading to Orlando to catch up on cutting-edge genome science with several thousand of our nearest and dearest … more »

Posted in Blog | Tagged , | Comments Off on ASHG 2017: Big Studies, Big Names, and Big DNA

Circulating Tumor DNA Easier to Spot with Size Selection

Posted on October 10, 2017 by Alex

A bioRxiv preprint from scientists at Cancer Research UK and Cambridge University Hospitals offers a look at how DNA size selection can be used to enhance results of circulating tumor DNA studies. Their analysis indicates that adding a simple sizing … more »

Posted in Blog | Tagged , , | Comments Off on Circulating Tumor DNA Easier to Spot with Size Selection

Poster: Gauging Repeat Expansion Size Quickly for Clinical Use

Posted on October 6, 2017 by Alex

Patients with hereditary ALS-FTLD (Lou Gehrig’s disease, marked by frontotemporal lobar degeneration) typically have a hexanucleotide repeat expansion in C9orf72. The size of that repeat expansion can be indicative of age of onset, severity of symptoms, and more, so it’s … more »

Posted in Blog | Tagged | Comments Off on Poster: Gauging Repeat Expansion Size Quickly for Clinical Use

It’s Baaack! Festival of Genomics Returns to Beantown

Posted on September 28, 2017 by Alex

It’s time for a genomics party! The Festival of Genomics returns to Boston next week, and we’re already looking forward to it. Sage is proud to be a sponsor and exhibitor at this great event, which brings together more than … more »

Posted in Blog | Tagged | Comments Off on It’s Baaack! Festival of Genomics Returns to Beantown

What’s the difference between the 4-10 Kb vs2 and 6-10 Kb vs3 high pass protocols?

Posted on September 15, 2017 by Alex

Customers may have noticed two very similar cassette definitions; 0.75%DF Marker S1 high-pass 4-10kb vs2 and 0.75%DF Marker S1 High-Pass 6-10kb vs3. Since these two protocols cover a similar range, they might seem a bit redundant. However, both of these … more »

Posted in Blog, Tips | Tagged , , | Comments Off on What’s the difference between the 4-10 Kb vs2 and 6-10 Kb vs3 high pass protocols?

Scientists Compare PacBio, Oxford Nanopore Transcriptome Results

Posted on September 14, 2017 by Alex

We enjoy a good technology evaluation as much as the next scientist, particularly when it comes to sequencing. So we were quite interested in a recent F1000Research publication about long-read sequencing platforms from researchers at the University of Iowa, the … more »

Posted in Blog | Tagged , | Comments Off on Scientists Compare PacBio, Oxford Nanopore Transcriptome Results