Transcription-associated mutation promotes RNA complexity in highly expressed genes — a major new source of selectable variation

February 2018

Shengkai Pan, Michael Bruford, Yusong Wang, Zhenzhen Lin, et al.


In this project, researchers studied transcriptomes in falcons, mice, and chickens and found that highly expressed genes are more likely to alternatively spliced. They also studied methylation patterns and its effect on alternative splicing. For this work, the team used SageELF to size and separate fractions for Iso-Seq analysis on the PacBio RS II system.


Molecular Biology and Evolution
doi: 10.1093/molbev/msy017

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