Next-Generation Sequence Analysis of Cancer Xenograft Models

Fernando J. Rossello, Richard W. Tothill, Kara Britt, Kieren D. Marini, Jeanette Falzon, David M. Thomas, Craig D. Peacock, Luigi Marchionni, Jason Li, Samara Bennett, Erwin Tantoso, Tracey Brown, Philip Chan, Luciano G. Martelotto, D. Neil Watkins

The authors looked at using xenografts as preclinical models for NGS cancer studies. The authors were able to show that mouse specific sequence was easily distinguished from human small cell lung cancer sequences. Pippin Prep size selection was used for whole genome library construction for the Illumina HiSeq.

PLoS ONE 8(9): e74432

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