November 2014
Authors:
Edmond Chipumuro, Eugenio Marco, Camilla L. Christensen, Nicholas Kwiatkowski, Tinghu Zhang,Clark M. Hatheway, Brian J. Abraham, Bandana Sharma, Caleb Yeung, Abigail Altabef, Antonio Perez-Atayde, Kwok-Kin Wong, Guo-Cheng Yuan, Nathanael S. Gray, Richard A. Young, and Rani E. George
Info:
Scientists from Harvard and MIT inhibited cyclindependent kinase 7 (CDK7) in neuroblastoma cells and found significant suppression of MYC oncoproteins. In a mouse model, the effect was notable shrinkage of the tumor. Libraries were size-selected for 200 bp to 400 bp using Pippin Prep prior to sequencing on an Illumina HiSeq 2000.
Citation:
Cell (2014)
dx.doi.org/10.1016/j.cell.2014.10.024