Co-chaperone Hsp70/Hsp90 organizing protein (Hop) is Required for Transposon Silencing and piRNA Biogenesis

February 2017

Authors:
Joseph A. Karam, Rasesh Y. Parikh, Dhananjaya Nayak, David Rosenkranz and Vamsi K. Gangaraju

Info:
Scientists from South Carolina and Mainz, Germany, studied Hop, a co-chaperone that interacts with a piRNA in Drosophila. They found that knocking down Hop activates transposons and that it has an important role in maintaining genome integrity. RNA-seq was performed on an Illumina HiSeq 2500 after Pippin Prep was used for size selection.

Citation:
Journal of Biological Chemistry
doi: 10.1074/jbc.C117.777730

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