Pharmacologic activation of estrogen receptor β increases mitochondrial function, energy expenditure, and brown adipose tissue

January 2017

Suriyan Ponnusamy, Quynh T. Tran, Innocence Harvey, Heather S. Smallwood, et al.

Scientists in Memphis, Tenn., studied obesity in mice, finding that estrogen receptor β and its ligands had a strong anti-obesity effect, reducing weight gain and adiposity in mice without any changes to activity levels or food intake. This could indicate a new opportunity for safe anti-obesity therapeutics in humans. For this project, Pippin Prep was used for library sizing prior to sequencing on an Ion Torrent Proton.

The FASEB Journal vol. 31 no. 1 266-281

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