Category Archives: Blog

PELE-seq Increases SNP Calling Accuracy by Reducing Sequencing Errors

Posted on July 27, 2016 by Alex

Scientists at the University of Oregon have published a new method to detect PCR and sequencing errors that should help other researchers track rare SNPs with greater accuracy. PELE-seq, which gets our vote for best new protocol name, can be … more »

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Low-Coverage Sequencing No Challenge for Structural Variant Detection

Posted on July 21, 2016 by Alex

Is it really possible to detect somatic structural variants accurately from a single sequencing read? A new protocol from scientists at the Albert Einstein College of Medicine in New York and Voronezh State University in Russia was designed to do … more »

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Sage Sizing Platforms Recommended for 10x Genomics Libraries

Posted on July 18, 2016 by Alex

We’re pleased to report that 10x Genomics has released a new sample prep protocol for its Chromium platform that includes the BluePippin and PippinHT size selection platforms from Sage Science. 10x Genomics has gotten a lot of attention in recent … more »

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Double Pippin for Optimized RAD-seq

Posted on July 13, 2016 by Alex

Scientists in China and the UK recently published an open-access optimized protocol for RAD-seq in the Theoretical and Applied Genetics journal. The method is targeted at large studies of plants and enables users to specify sequence coverage parameters. From lead … more »

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Podcast: Kari Stefansson on 20 Years of Human Genomics

Posted on July 8, 2016 by Alex

Mendelspod has turned out another terrific podcast, this one with Kari Stefansson, and we’re proud to have sponsored the thought-provoking discussion. As most people in the field know, Stefansson earned his fame as founder of DeCode Genetics, which has spent … more »

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Scientists Use Multiple Technologies to Produce High-Quality Chinese Genome Assembly

Posted on July 5, 2016 by Alex

A newly reported genome assembly of a Chinese individual, generated by scientists in China and the US, used long-read PacBio sequencing, short-read Illumina data, and BioNano Genomics physical maps to achieve remarkably high accuracy and contiguity. Along the way, the … more »

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New GIAB Publication Characterizes Seven Genomes with 12 Technologies

Posted on June 27, 2016 by Alex

The Genome in a Bottle Consortium is on a roll — and if you haven’t checked out the latest paper in Scientific Data, you’re missing out. “Extensive sequencing of seven human genomes to characterize benchmark reference materials” comes from lead … more »

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NCSU Scientist Incorporates Genomics for Better Blueberry Resources

Posted on June 21, 2016 by Alex

Hamid Ashrafi is working to breed higher-quality blueberries that are amenable to mechanical harvest, larger in size, tastier, and have a longer shelf life. As an assistant professor at North Carolina State University, Ashrafi is bringing genomic tools to a … more »

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SageELF Offers Unique Advantages for Long-Range Sequencing and CNV Analysis

Posted on June 14, 2016 by Alex

We released our SageELF instrument two years ago, and seeing how scientists have adopted it for various NGS pipelines has been a wonderful journey. If you haven’t noticed these great uses, we’ll get you up to speed with this quick … more »

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The Conference Month: Prepping for PacBio, ASM, FoG

Posted on June 1, 2016 by Alex

It’s June, and you know what that means: genomics conference season is back! The Sage team will be attending several events this month and we hope to see you at least once. We kick off next week with PacBio’s annual … more »

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